Smithkline Beecham - PharmaKB

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Company ReportsSmithkline Beecham

Smithkline Beecham

GSK plc, formerly GlaxoSmithKline plc, is a British multinational pharmaceutical and biotechnology company with global headquarters in London, England. Established in 2000 by a merger of Glaxo Wellcome and SmithKline Beecham.[n 1] GSK is the tenth largest pharmaceutical company and #294 on the 2022 Fortune Global 500, ranked behind other pharmaceutical companies China Resources, Sinopharm, Johnson & Johnson, Pfizer, Roche, AbbVie, Novartis, Bayer, and Merck.

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Trade Name	Drug Name	Approved	Patent Expires	Indication
Avaglim	Glimepiride, Rosiglitazone	2006-06-27	2027-2028	Type 2 diabetes mellitus
Avandamet	Metformin, Rosiglitazone	2003-10-20	2023-2035	Type 2 diabetes mellitus
Avandia	Rosiglitazone	2000-07-11		Type 2 diabetes mellitus
Axid	Nizatidine	1988-04-12		Gastroesophageal reflux, Helicobacter infections, Peptic esophagitis, Stomach ulcer, Duodenal ulcer, Dyspepsia, Zollinger-ellison syndrome, Urticaria, Heartburn
Dynacirc	Isradipine	1990-12-20		Hypertension, Variant angina pectoris
Evotopin	Topotecan	1997-04-15		Ovarian neoplasms, Non-small-cell lung carcinoma, Small cell carcinoma, Uterine cervical neoplasms, Small cell lung carcinoma
Nyracta	Rosiglitazone	2000-07-11		Type 2 diabetes mellitus
Probenecid colchicine	Colchicine, Probenecid	1982-01-01	2028-2037	Gonorrhea, Biliary liver cirrhosis, Amyloidosis, Neurosyphilis, Familial mediterranean fever, Gout
Relafen	Nabumetone	1991-12-24		Rheumatoid arthritis, Pain, Inflammation, Osteoarthritis
Venvia	Rosiglitazone	2000-07-11		Type 2 diabetes mellitus

Clinical Trials

Therapeutic Areas:

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Classification:

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Approval:

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Status:

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Phases:

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Drug Name

Phase 1

Phase 2

Phase 3

Phase 4

Indication

,

breast neoplasms

,

endometrial neoplasms

,

glucose intolerance

,

metabolic syndrome

,

triple negative breast neoplasms

,

type 2 diabetes mellitus

,

diabetes mellitus

,

insulin resistance

,

,

,

patient preference

,

,

pituitary acth hypersecretion

,

,

prediabetic state

,

pancreatic neoplasms

,

,

multiple myeloma

,

,

plasma cell neoplasms

,

ovarian neoplasms

,

ovarian epithelial carcinoma

,

,

leukoencephalopathies

,

progressive multifocal leukoencephalopathy

,

myeloid leukemia acute

,

congenital abnormalities

,

megakaryoblastic leukemia acute

,

monocytic leukemia acute

,

myelomonocytic leukemia acute

,

erythroblastic leukemia acute

,

non-hodgkin lymphoma

,

type 2 diabetes mellitus

,

diabetes mellitus

Metformin hydrochloride

healthy volunteers/patients

type 2 diabetes mellitus

,

diabetes mellitus

,

insulin resistance

,

,

respiratory insufficiency

,

rheumatoid arthritis

,

respiratory distress syndrome

,

severe acute respiratory syndrome

,

,

head and neck neoplasms

,

chronic urticaria

,

,

venous thrombosis

,

postthrombotic syndrome

,

immunoglobulin light-chain amyloidosis

,

smoldering multiple myeloma

,

,

large b-cell lymphoma diffuse

,

b-cell lymphoma

,

myelodysplastic syndromes

,

myelomonocytic leukemia chronic

,

,

,

multiple myeloma

,

plasma cell neoplasms

,

,

precursor cell lymphoblastic leukemia-lymphoma

,

lymphoid leukemia

ventilator-associated pneumonia

,

diabetes mellitus

,

diabetic neuropathies

,

,

attention deficit disorder with hyperactivity

postoperative nausea and vomiting

,

,

viral hepatitis human

,

,

neurologic manifestations

,

brain neoplasms

,

,

,

biliary tract neoplasms

,

,

follicular lymphoma

,

,

microsatellite instability

,

squamous cell neoplasms

,

large cell carcinoma

,

chronic obstructive pulmonary disease

,

,

cholangiocarcinoma

,

,

mouth neoplasms

,

oropharyngeal neoplasms

,

laryngeal neoplasms

,

hypopharyngeal neoplasms

,

b-cell lymphoma marginal zone

,

mantle-cell lymphoma

,

endometrial neoplasms

,

transitional cell carcinoma

,

uterine cervical neoplasms

,

cutaneous malignant melanoma

,

type 2 diabetes mellitus

,

diabetes mellitus

,

non-small-cell lung carcinoma

,

,

,

,

breast neoplasms

,

,

communicable diseases

,

,

chronic hepatitis c

,

,

,

neoplasm metastasis

,

,

colorectal neoplasms

,

stomach neoplasms

,

triple negative breast neoplasms

,

,

squamous cell carcinoma of head and neck

,

esophageal neoplasms

,

ovarian neoplasms

,

,

chronic hepatitis

,

,

,

squamous cell carcinoma

,

head and neck neoplasms

,

sleep initiation and maintenance disorders

,

,

clostridium infections

,

multiple myeloma

,

plasma cell neoplasms

,

hodgkin disease

,

,

ovarian epithelial carcinoma

,

migraine disorders

,

castration-resistant prostatic neoplasms

,

pancreatic neoplasms

,

,

essential hypertension

,

nasopharyngeal neoplasms

,

acquired immunodeficiency syndrome

,

,

chronic renal insufficiency

,

kidney diseases

,

hepatocellular carcinoma

,

general anesthesia

,

neuromuscular blockade

,

intraabdominal infections

,

urinary tract infections

,

malignant mesothelioma

,

,

postmenopausal osteoporosis

,

hypercholesterolemia

,

alzheimer disease

,

,

erectile dysfunction

,

renal cell carcinoma

,

surgical wound infection

,

bacterial skin diseases

,

bacterial infections

,

staphylococcal infections

,

,

immunologic deficiency syndromes

,

urinary bladder neoplasms

,

,

type 1 diabetes mellitus

,

cytomegalovirus infections

,

,

glucose metabolism disorders

,

metabolic diseases

,

endocrine system diseases

,

allergic rhinitis

,

,

allergic rhinitis seasonal

,

liver neoplasms

,

fallopian tube neoplasms

,

,

,

bacterial pneumonia

,

,

,

,

,

hepatic insufficiency

,

,

prostatic hyperplasia

,

,

,

cognitive dysfunction

,

,

,

prostatic neoplasms

,

plexiform neurofibroma

,

neurofibromatosis 1

,

hereditary breast and ovarian cancer syndrome

,

,

central nervous system neoplasms

,

nervous system neoplasms

,

rheumatoid arthritis

,

,

hip osteoarthritis

,

surgical blood loss

,

replacement arthroplasty hip

type 1 diabetes mellitus

,

,

diabetes mellitus

appendiceal neoplasms

,

cystadenocarcinoma

,

neoplasms by histologic type

,

sezary syndrome

,

,

hematologic diseases

,

chromosome aberrations

,

female genital neoplasms

,

castration-resistant prostatic neoplasms

,

leukemia myeloid chronic atypical bcr-abl negative

,

,

,

cutaneous malignant melanoma

,

deltaretrovirus infections

,

htlv-i infections

,

composite lymphoma

,

pelvic neoplasms

,

abdominal neoplasms

,

urogenital neoplasms

,

gastrointestinal stromal tumors

,

liver cirrhosis

,

squamous cell carcinoma of head and neck

,

,

plasmablastic lymphoma

,

invasive hydatidiform mole

,

,

adult t-cell leukemia-lymphoma

,

non-small-cell lung carcinoma

,

aids-related lymphoma

,

myeloid leukemia chronic-phase

,

thyroid neoplasms

,

head and neck neoplasms

,

intestinal neoplasms

,

primary effusion lymphoma

,

,

gastrointestinal neoplasms

,

germ cell and embryonal neoplasms

,

,

desmoplastic small round cell tumor

,

thyroid diseases

,

cholangiocarcinoma

,

squamous cell carcinoma

,

ductal carcinoma

,

t-cell lymphoma cutaneous

,

,

urologic neoplasms

,

,

primitive neuroectodermal tumors

,

primary myelofibrosis

,

uterine cervical neoplasms

,

salivary gland neoplasms

,

breast carcinoma in situ

,

anaplastic thyroid carcinoma

,

thymus neoplasms

,

embryonal rhabdomyosarcoma

,

thrombocytopenia

,

healthy volunteers/patients

,

,

hypersensitivity

,

intestinal diseases

,

hairy cell leukemia

,

lymphomatoid granulomatosis

,

mycosis fungoides

,

,

myeloid leukemia accelerated phase

,

plasma cell leukemia

,

adenoid cystic carcinoma

,

,

,

carcinoma in situ

,

endocrine gland neoplasms

,

bile duct neoplasms

,

esophageal squamous cell carcinoma

,

graft vs host disease

,

,

alveolar rhabdomyosarcoma

,

neurotoxicity syndromes

,

,

neuroendocrine tumors

,

nervous system neoplasms

,

,

intraocular lymphoma

,

castleman disease

,

,

phenylketonurias

,

,

hereditary breast and ovarian cancer syndrome

,

adenomyoepithelioma

,

testicular neoplasms

,

,

neuroepithelial neoplasms

,

islet cell adenoma

,

,

pancreatic ductal carcinoma

,

,

chemotherapy-related cognitive impairment

,

immunoglobulin light-chain amyloidosis

,

,

renal insufficiency

,

human herpesvirus 8

,

cortical blindness

,

blastic plasmacytoid dendritic cell neoplasm

,

antineoplastic combined chemotherapy protocols

,

paranasal sinus neoplasms

,

febrile neutropenia

,

neoplasms by site

,

thromboembolism

,

,

,

gene rearrangement

,

prolymphocytic leukemia t-cell

,

,

,

cardiovascular abnormalities

,

prosthesis failure

,

,

essential thrombocythemia

,

polycythemia vera

,

diffuse intrinsic pontine glioma

,

hemolytic anemia autoimmune

,

hemolytic anemia

,

,

experimental neoplasms

,

fibrous tissue neoplasms

,

optic nerve glioma

,

oligodendroglioma

,

disease progression

,

,

neurofibromatosis 1

,

neurofibromatoses

,

,

,

,

,

zollinger-ellison syndrome

,

post-traumatic stress disorders

,

,

,

,

adenoviridae infections

,

respiratory aspiration

,

mouth neoplasms

,

,

large cell carcinoma

,

vaginal neoplasms

,

vulvar neoplasms

,

endometrial stromal sarcoma

,

minimally invasive surgical procedures

,

cystic fibrosis

,

ovarian neoplasms

,

neoplasm metastasis

,

,

stomach neoplasms

,

,

ovarian epithelial carcinoma

,

monocytic leukemia acute

,

myelomonocytic leukemia acute

,

,

,

erythroblastic leukemia acute

,

inflammatory breast neoplasms

,

,

megakaryoblastic leukemia acute

,

prostatic neoplasms

,

male breast neoplasms

,

kidney neoplasms

,

,

,

endometrial neoplasms

,

fallopian tube neoplasms

,

bcr-abl positive chronic myelogenous leukemia

,

esophageal neoplasms

,

,

congenital abnormalities

,

precursor t-cell lymphoblastic leukemia-lymphoma

,

myeloproliferative disorders

,

b-cell chronic lymphocytic leukemia

,

transitional cell carcinoma

,

myelomonocytic leukemia chronic

,

cardiovascular diseases

,

small cell lung carcinoma

,

,

colorectal neoplasms

,

,

pancreatic neoplasms

,

endometrioid carcinoma

,

hematologic neoplasms

,

,

b-cell lymphoma marginal zone

,

refractory anemia with excess of blasts

,

large-cell lymphoma immunoblastic

,

,

,

,

basophilic leukemia acute

,

malignant fibrous histiocytoma

,

neoadjuvant therapy

,

,

myelodysplastic-myeloproliferative diseases

,

t-cell leukemia

,

eosinophilic leukemia acute

,

acinar cell carcinoma

,

serous cystadenocarcinoma

,

renal cell carcinoma

,

peritoneal neoplasms

,

malignant mesothelioma

,

,

precursor b-cell lymphoblastic leukemia-lymphoma

,

waldenstrom macroglobulinemia

,

extranodal nk-t-cell lymphoma

,

mucinous cystadenocarcinoma

,

ductal carcinoma breast

,

,

ureteral neoplasms

,

mucinous adenocarcinoma

,

hemangiosarcoma

,

neuroectodermal tumors

,

synovial sarcoma

,

neurofibrosarcoma

,

refractory anemia

,

urethral neoplasms

,

primitive neuroectodermal tumors peripheral

,

benign fibrous histiocytoma

,

ganglioneuroblastoma

,

brain neoplasms

,

myelomonocytic leukemia juvenile

,

nerve sheath neoplasms

,

,

adrenocortical carcinoma

,

drug-related side effects and adverse reactions

,

,

eyelid neoplasms

,

residual neoplasm

,

hypereosinophilic syndrome

,

,

,

acquired immunodeficiency syndrome

,

clear cell adenocarcinoma

,

left ventricular dysfunction

,

,

central nervous system neoplasms

,

lobular carcinoma

,

,

,

dermatofibrosarcoma

,

uterine neoplasms

,

reactive arthritis

,

myeloid sarcoma

,

gallbladder neoplasms

,

clear cell sarcoma

,

induction chemotherapy

,

chemotherapy-induced febrile neutropenia

,

,

connective and soft tissue neoplasms

,

epstein-barr virus infections

,

,

colonic neoplasms

,

b-cell leukemia

,

adjuvant chemotherapy

,

,

ventricular dysfunction

,

solitary fibrous tumors

,

hemangiopericytoma

,

pheochromocytoma

,

lymphadenopathy

,

pathologic complete response

,

alveolar soft part sarcoma

,

rectal neoplasms

,

adenosquamous carcinoma

,

interdigitating dendritic cell sarcoma

,

lymphatic diseases

,

hemophagocytic lymphohistiocytosis

,

pulmonary blastoma

,

,

nasopharyngeal carcinoma

,

nasopharyngeal neoplasms

,

,

postoperative complications

,

perivascular epithelioid cell neoplasms

,

mesenchymal chondrosarcoma

,

,

plasma cell granuloma

,

choroid plexus neoplasms

,

retinal neoplasms

,

,

extravasation of diagnostic and therapeutic materials

,

progression-free survival

,

beckwith-wiedemann syndrome

,

adrenal cortex neoplasms

,

unknown primary neoplasms

,

respiratory insufficiency

,

connective tissue neoplasms

,

diastolic heart failure

,

,

positron-emission tomography

,

adolescent development

,

breast neoplasms

,

,

,

myeloid leukemia acute

,

precursor cell lymphoblastic leukemia-lymphoma

,

,

non-hodgkin lymphoma

,

large b-cell lymphoma diffuse

,

myeloid leukemia

,

,

b-cell lymphoma

,

triple negative breast neoplasms

,

lymphoid leukemia

,

,

hodgkin disease

,

liver neoplasms

,

myelodysplastic syndromes

,

,

hepatocellular carcinoma

,

multiple myeloma

,

follicular lymphoma

,

t-cell lymphoma

,

t-cell lymphoma peripheral

,

burkitt lymphoma

,

plasma cell neoplasms

,

,

,

mantle-cell lymphoma

,

urinary bladder neoplasms

,

biphenotypic leukemia acute

,

,

large-cell lymphoma anaplastic

,

rhabdomyosarcoma

,

cardiomyopathies

,

promyelocytic leukemia acute

,

philadelphia chromosome

,

immunoblastic lymphadenopathy

,

,

enteropathy-associated t-cell lymphoma

,

brain stem neoplasms

,

lymphoproliferative disorders

,

takotsubo cardiomyopathy

,

non-muscle invasive bladder neoplasms

,

breast diseases

,

second primary neoplasms

,

,

,

systolic heart failure

,

mediastinal neoplasms

,

,

male infertility

,

,

circulating neoplastic cells

,

alopecia areata

,

,

peripheral nervous system diseases

,

myocardial infarction

,

wounds and injuries

,

carcinoid tumor

,

,

erectile dysfunction

,

diabetic neuropathies

,

,

biliary tract neoplasms

,

,

,

ataxia telangiectasia

,

,

cerebellar ataxia

,

cardiac rehabilitation

,

chromosome disorders

,

gonadal disorders

,

,

cerebrovascular disorders

,

retroperitoneal neoplasms

,

endomyocardial fibrosis

,

pseudomyxoma peritonei

,

therapeutic chemoembolization

,

liver transplantation

,

malignant carcinoid syndrome

,

,

hyperlipidemias

,

diabetes mellitus

,

metabolic syndrome

,

hyperlipoproteinemias

,

intraductal carcinoma noninfiltrating

,

,

echocardiography

,

environmental biomarkers

,

myocardial contraction

,

physiological sexual dysfunction

,

,

,

cognitive dysfunction

,

peripheral arterial disease

,

peripheral vascular diseases

,

radiation injuries

,

eye abnormalities

,

,

gastrointestinal microbiome

,

coronary artery disease

,

microvascular angina

,

,

,

aortic valve stenosis

,

serotonin syndrome

,

,

cardiac imaging techniques

,

,

early detection of cancer

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